Scientists have found the cause of the disease geniuses

Scientists have found the cause of the disease geniusesIdentified the gene that causes manic-depressive psychosis (TIR), and it opens new perspectives in the treatment of one of the most common and severe mental illness. A study in the US shows that one damaged gene in 10 percent of cases are guilty of causing the disease, leading to a sharp change of mood, which is also called bipolar disorder and who suffers every 200 people. It is believed that he was exposed to the greatest writers and artists. Mutation, discovered by researchers at the University of California, makes the owners of the gene are sensitive to substances of the brain that controls mood, and this leads to the fact that patients euphoria followed by bouts of deep depression. This condition is often treated with antipsychotic drugs, but existing methods approximately half of patients do not bring relief. The researchers hope that the discovery of the genetic roots will help to develop more effective treatments. Many of the existing drugs have unpleasant side effects like tremor, and there is evidence that under certain circumstances, common antidepressants can be dangerous for patients with TIR. Although the name of the disease is the word "depressed", it has little in common with classic depression. Like schizophrenia, with which it may be connected, this disease can cause hallucinations and inappropriate behavior. Today psychiatrists prefer the term "bipolar disorder", which allows to distinguish between TIR and depression. In the stage of euphoria in patients open incredible creative possibilities. This disease suffered, for example, Charles Dickens, Ernest Hemingway, Vincent van Gogh. But manic-depressive psychosis, destroys the ability to stay at work or maintain relationships with other people. About a quarter of patients at some point, attempt suicide, and half of them brings their intention to end. That bipolar disorder has a genetic origin, known for a long time, because the disease is inherited, but only now selected gene, which plays a key role. New research article which was published today in the journal Molecular Psychiatry, suggest that one out of ten cases, the emergence of the disease can be explained by damage to a particular stretch of DNA. The gene, named GRK3, was identified in the analysis of the stories of more than 400 families, where there were cases of bipolar disorder. These people have provided samples of their DNA for research. Scientists have discovered that a certain mutation GRK3, known as P-5, has been observed in patients TIR three times as often. GRK3 controls the sensitivity of the brain to signal substances, in particular dopamine, which affects mood. Peter Barrett, who conducted the genetic analysis, says: "the P-5 is a plot of GRK3, which controls the activation and deactivation of the gene. A defect in the P-5 can not in time to turn on and off gene". As a result, the brain sometimes too vigorously responds to dopamine, and then there is euphoria, and sometimes does not respond to it at all, and then depression. Now scientists are conducting further studies to confirm the relationship between gene and disease. Then they will try to develop the product, corrective susceptibility of patients to dopamine and other chemical agents in the brain. Mark Henderson.



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